Trillium Theraputics Inc
Pharmaceutical Products in Etobicoke

CANCER STEM CELLS CANCER STEM CELLSThe cancer stem cell (CSC) concept postulates that the growth of tumors is driven by a rare population of dedicated cells that have stem cell-like properties, including self-renewal. This and subsequent work clearly established that AML is organized as a cellular hierarchy, sustained by a population of LSCs. Although the CSC concept was first postulated in the 1960s, it wasn't until 1994 that proof of their existence was demonstrated, when John Dick and colleagues in Toronto isolated CSCs (known as leukemic stem cells, or LSCs) from bulk acute myeloid leukemia (AML) cells. While the bulk of a tumor consists of rapidly proliferating cells and post-mitotic, neither of which is capable of self-renewal, differentiated cells, a small population of CSCs provides for long-term maintenance of the cancer. More recently, colon, breast, brain, including solid tumors such as bladder, CSCs have been identified in many other human malignancies, ovarian and prostate cancers.There is accumulating evidence that CSCs are resistant to conventional chemotherapies and radiation.